RapamycinFungusV1, Main, Exploration, bibRecord, 001255

Target of rapamycin (TOR) in nutrient signaling and growth control.

Identifieur interne : 001255 ( Main/Exploration ); précédent : 001254; suivant : 001256

Target of rapamycin (TOR) in nutrient signaling and growth control.

Auteurs : Robbie Loewith [Suisse] ; Michael N. Hall

Source :

Genetics [ 1943-2631 ] ; 2011.

RBID : pubmed:22174183

Descripteurs français

KwdFr :
- Protéines de Saccharomyces cerevisiae (physiologie), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (métabolisme), Transduction du signal (physiologie).
MESH :
- croissance et développement : Saccharomyces cerevisiae.
- métabolisme : Saccharomyces cerevisiae.
- physiologie : Protéines de Saccharomyces cerevisiae, Transduction du signal.

English descriptors

KwdEn :
- Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (physiology), Signal Transduction (physiology).
MESH :
- chemical , physiology : Saccharomyces cerevisiae Proteins.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- physiology : Signal Transduction.

Abstract

TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.

DOI: 10.1534/genetics.111.133363
PubMed: 22174183
PubMed Central: PMC3241408

Affiliations:

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Le document en format XML

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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Target of rapamycin (TOR) in nutrient signaling and growth control.

Target of rapamycin (TOR) in nutrient signaling and growth control.

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